objective(s):transporters have an important role in pharmacokinetics of drugs. inhibition or induction of drug transporters activity can affect drug absorption, safety, and efficacy. p-glycoprotein (p-gp) is the most important membrane transporter that is responsible for active efflux of drugs. it is important to understand which drugs are substrates, inhibitors, or inducers of p-gp to minimize...

Desferroxamine (Desferal) is used tochelate iron in thalassemia, a disease of very high prevalence in various parts of lran. We have investigated intestinal zinc absorption in Desferal-treated rats which, in pilot experiments, showed low serum levels of both iron and zinc. Intraperitoneal administration of ten 0.5 g doses of Desferal (one injection every other day) to male rats produced sev...

Under high altitude conditions, the effects of vitamin E (α-tocopherol) on growth performance, intestinal morphology (villus size and type), and absorptive surface area of broiler chickens were evaluated. Chickens were fed diets supplemented with 0, 100, 200 or 400 IU/kg vitamin E for 42 days. On days 14, 28 and 42, birds were sacrificed and three segments of small intestine were dissected. The...

desferroxamine (desferal) is used tochelate iron in thalassemia, a disease of very high prevalence in various parts of lran. we have investigated intestinal zinc absorption in desferal-treated rats which, in pilot experiments, showed low serum levels of both iron and zinc. intraperitoneal administration of ten 0.5 g doses of desferal (one injection every other day) to male rats produced severe ...